PDF | With clinical psychiatrist Rick Strassman’s DMT: The Spirit Molecule as a vehicle, the , 83) enables transit of the life-force from this life to the next. DMT: The Spirit Molecule and millions of other books are available for instant access. .. Paperback: pages; Publisher: Park Street Press (January ). Editorial Reviews. Review. “Strassman’s important research contributes to a growing (Jule Klotter, Townsend Letter for Doctors & Patients – July, ).

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In its efforts to mainstream psychedelics, the biomedical model runs the risk of proclaiming and defending particular dogmas and orthodoxies. These raise the risk of stifling inquiry into the full psychedelic experience: The biomedical research model has been extraordinarily successful in re-introducing psychedelic drugs to the larger scientific community and popular culture.

Moderate doses, strict attention to non-drug factors, and a modest relationship with the media all have contributed Several theories about DMT have aroused these strong reactions. Creating a field of psychedelic medicine opens the window to potential benefits and risks by increasing their accessibility. Rescheduling psychedelics out of the highly restrictive Schedule I fmt necessary for this to occur. Additional issues of public health policy must be determined, and who takes the lead in shaping these policies requires careful attention.

Backlash against the wider biomedical availability of psychedelic drugs is likely at some point. However, we may take steps that minimize causes of a potential backlash.

Rick Strassman

One of these steps is to avoid overreaching. Any failure to maintain intellectual rigor and honesty in such a highly controversial field will not serve the research community well when media coverage turns negative for any reason.

The worst thing we can hear is: Strassman has been exploring models for the DMT effect focusing primarily on the Old Testament concept of prophecy. Prophecy is a spiritual experience which takes into account the apparently external, free-standing nature of the DMT “worlds,” in which one’s sense of self is highly preserved and interactive.

Rick Strassman – Wikipedia

The Old Testament concept of prophecy provides an alternative to other models that borrow more heavily from Eastern religious systems, and those of Latin American shamanism. The notion of prophecy also deals directly with ethical and moral concerns, adding a crucial element to our ability to understand and integrate the content of the psychedelic experience.

He is developing these ideas in his next book, The Soul of Prophecy, due to appear in He is also President and co-founder of the Cottonwood Research Foundation, which is dedicated to consciousness research.

Led to this substance through his earlier study of the pineal gland as a potential biological locus for spiritual experiences, he administered several hundred doses of DMT to approximately 60 volunteers between and He wrote about this research in the popular book, DMT: The Spirit Molecule, which has sold overcopies, has been translated into 12 languages, and is now available as an audio-book. It also inspired an independent documentary by the same name, picked up by Warner Bros distributing in Fall, With three distinguished collaborators, he co-authored Inner Paths to Outer Space, which looks more carefully at the common “other worlds” experience that volunteers frequently reported during his research.

The most extensive scientific study of the mental and perceptual effects of a psychedelic drug since the s. A dazzling journey through psychedelic drug experimentation and a tantalizing peek into a new model of how the brain and mind work. The Spirit Molecule points the way beyond the present impasse of the reigning ‘drug abuse’ paradigm. This book is essential reading for anyone with an interest in the mind, philosophy, the nature of reality, and spirituality. Should We Loosen the Restrictions on Psychedelics?

Rick’s Blog Mainstreaming psychedelics. Are we there yet? Misguided Mainstreaming of Psychedelic Drugs: Challenging Experiences October 25, New Publication The psychedelic religion of mystical consciousness.

Click molecuke to read. About Rick SinceDr. Buy the Books If you order books directly from me, I will sign and inscribe them to you. Rick Strassman MD performed the first new human studies with psychedelic drugs in the US in over 20 years.


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Product details – OBD2 software moDiag ultimate / moDiag expert

This is the best adapter if you want the fastest PID read speed. There have been user reports of some of these adapters being faulty like some of the clone adapters. If Torque reports there is an issue with the adapter, check with PLX devices support for more help or getting a diamwx Support forums. If you are using the USB version of this adapter then be aware that you will need to make sure the adapter uses an FTDI or Prolific usb to serial converter chip and have an android device running Android 3.

If you are using adapters with a bluetooth MAC address of FF then be aware that these adapters will not work with other adapters nearby with the same address and should be avoided if you plan to use multiple adapters Some of these units also appear to have pairing dx0 – some of the super dc70 adapters have this flaw. This is a list of adapters that Torque has been tested with which work with OBD2 compliant vehicles: The adapters do not determine what sensors are or are not available, they are all the same in this respect Contents.

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Fully checked and tested before dispatch – This is the official version of this adapter others that look like it are lesser quality clones Main Site. Upgradable firmware Support Forums. New versions of this adapter appear to require a manual ‘link’ button to be pressed to wake it up before Torque will be able to connect.

If you use automatic logging you may wish to avoid this adapter There have been user reports of some of these adapters being faulty like some of the clone adapters. Some units seem to suffer poor build quality and reliability issues.

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If you have connection issues, or displays randomly ‘pausing’ in the d7x0 then it is most likely an adapter issue. User upgradeable via free downloads, Support forums Reports of good customer support. The protocol was discovered, however the adapter proved to be too slow to be of any use. Not ELM compatible, uses their own closed protocol.


Footsteps. By Umm Zakiyyah. Ismael and Sarah have what every couple hopes to achieve. Stability, dedication, and a comfortable life. Footsteps by Umm Zakiyyah. 3 likes. Book. Footsteps by Umm Zakiyyah. Book. 3 people like this topic. Want to like this Page? Sign up for Facebook to get. Footsteps: a novel /​ Umm Zakiyyah. Author. Zakiyyah, Umm. Published. Suitland, MD: Al-Walaa Publications, []. Content Types. text. Carrier Types.

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Goodreads helps you keep track of books you want to read. Want to Read saving…. Want to Read Currently Zakiyyh Read. Refresh and try again.

Smashwords – Footsteps – a book by Umm Zakiyyah

Open Preview See a Problem? Thanks for telling us about the problem. Return to Book Page. Preview — Footsteps by Umm Zakiyyah. The journey began in If I Should Speak with Tamika Zakuyyah path of spiritual growth and direction, treaded at the hands of her college roommates, Fotsteps and Dee, two Muslims on opposite ends of their strength in Islam.

Footsteps, the third in a trilogy to follow Umm Zakiyyah’s A Voice, is a story that stands on its own in both impact and inspiration.

At the heart of the The journey began in If I Should Speak with Tamika Douglass’s path of spiritual growth and direction, treaded at the hands of her college roommates, Aminah and Dee, two Muslims on opposite ends of their strength in Islam.

At the heart of the novel is the story of Ismael, a forty-seven-year-old biracial son of a White mother and Black father, and Sarah, a forty-nine-year-old White daughter of the racist South. Married for twenty-six years and having accepted Islam on a journey they took together, the Ali pair has what every partnership hopes to achieve. Stability, dedication, and a comfortable life. As the story unfolds, the hairline fractures in their marriage become visible, and the fractures become splintering cracks as Sarah discovers a detrimental secret her husband has kept from her for four months.

In the face of his wife’s discovery, Ismael is torn between the love and security of his marriage, and the natural inclinations any man must temper in a world full of choices, and devastating consequences. Forming the thread that weaves the characters’ lives together is Alika Mitchell, a strikingly beautiful daughter of a mulatto mother and half-Nigerian father, who is conducting a multicultural research for her master’s, and who inspires in the reader questions that one is left to ponder long after the book is closed.

Paperbackpages. If I Should Speak 3. To see what your friends thought of this book, please sign up. To ask other readers questions about Footstepsplease sign up. I know a lot of women may take a certain stance that is footsteps in this book, but I feel that the author did a wonderful job conveying all the characters and their mind set. See 1 question jmm Footsteps…. Lists with This Book. This is a great book with a strong plot that took me with her to the story where each one of the characters tries to understand this life in the best way.

Umm Zakiyyahs books takes me behind my sight to think more about many things that i will face in my life even if I am not with her in some small details. Thank you Umm Footxteps. Feb 26, Hanna rated it liked it. Romance, Fiction Oh and for the people who have issues about reading books by Muslim authors: It’s a fiction book.

You will enjoy it. The best thing about this entire thing was that it was completely untypical fiction. There were so many racially diverse characters, which I have never seen before in any sort of Genre: There were so many racially diverse characters, which I have never seen before in any sort of literature.

And the fact that Umm Zakiyya chooses topics that are interesting to Muslims as well not just a typical story about a Muslim in high school who has the same problems as everyone else but not really zakiytah Muslim.

It’s such a compelling story that I think zskiyyah controversial issues well. My favorite of the three. Everyone seemed like an ideal Muslim, which tinged the story and made it a bit unrealistic.

Anyway my imagination could handle that because if it wasn’t u,m, the story would have been a hundred times more complex than it was.

The complexity of the story was easy to follow, I think even for non Muslims to understand. However, something I had trouble understanding was the divorce process. I think it should footwteps been explained a little more because I didn’t really know the ruling about 1 months or 3 months and I had no idea what was going on or if they really were divorced or what?

Okay and the whole issue of polygamy I understand a bby more why it shouldn’t be as tabooed as it is, but I understand that our reactions are also understandable. Haha okay this zkaiyyah a hard opinion to write about. I would never want to be in a shared relationship of course, but this book makes the readers understand that it is possible and that it is allowed and why it is in Islam. I’m still iffy about the fact that men’s nature is polygamous and woman’s nature is jealous I could see why people have issues about that.

The book not only sakiyyah into the nature of polygamy but also explores the reactions and relationships of all the people involved. I enjoyed how Kate, an outsider and non Muslims was more open to it than any of the Muslims.

Overall, I was satisfied with the conclusion of the story that while polygamy is allowed, a truly understanding person people is are needed to carry through and shouldn’t be attempted with any doubt in the heart. Race is honestly something I knew was an issue but never imagined it to be explored in fiction and I am satisfied with the result. Honestly if there wasn’t any Pakistani character, I might not have payed as much attention to it as I did when Zaid’s cultural views came into place.

I could see inadvertent? I love that Umm Zakiyyah allowed us glimpses of all the families, which really helped us to imagine an established Muslim society and how everything affected many families not just one. Of course I enjoyed the romance between Tamika and Sulayman and especially Aminah and Teddy this guy killed me ahaha he’s perfect Also: No romance is complete without a love triangle.

Jan 02, Sabrina rated it really liked it Shelves: This review has been hidden because it contains spoilers. To view it, click here. If you don’t plan on reading this book anytime in the next few years for example, because you are too young ; please DO NOT continue to read this review. I know you are really curious now, so all I will say is that a lot of the book covers an adult topic.

Just from reading the back of Footsteps, I knew the topic of polygyny was going to be part of the book. I think anyone can figure that out.

Umm Zakiyyah

Footsteps focuses on Aminah and Sulayman’s parents and while I don’t like perfect characters, reading about Sarah and Ismael’s thoughts and feelings about polygyny was frustrating at times.

My opinion of polygyny changed since high school when I first learned about the subject and even before reading Imm, but I think this book is good for those adults who have feelings for or against it just because Footsteps provides different perspectives on the subject.

I footsfeps think married and soon to be married people should read Footsteps for the same reason. Besides polygyny, marriage is also brought up in Footsteps a lot a subject that is becoming more and more relevant in my life I liked how the Nation of Islam was also brought up because it was explained and the difference it has to Islam which many people don’t know.

The characters of Nusaybah and Alika were interesting to read about and good choices for Footsetps Zakiyyah to include. I really wish that I had someone like Nusaybah in my life because of the way she explains things and Alika, although not so “innocent” was a wise character for the most part. This book was a little emotional, definitely interesting, and compared to the first two books in the trilogy, I enjoyed reading Footsteps more because this was the first time I read it and not rereading it like the other two.

View all 4 comments. Mar 28, notRahimeanymore rated it it was amazing. A continuation of the stories of the characters from the first two books – and this one deals with polygamy. It was a compelling read, although at times I felt like I was being hit over the zskiyyah with a ‘women are jealous by nature, men are polygamous by nature’ stick.

Considering the stance at the end of the book that seems to be the author’s I’m wondering if that zakiyysh supposed to be Ismael’s thought process? I felt uncomfortable at times, since it felt like the author was advocating polygamy f A continuation of the stories of the characters from the first two books – and this one deals with polygamy.

I felt uncomfortable at times, since it felt like the author was advocating polygamy for everyone, but by the end it’s clear that her stance is the same as mine: When I reviewed ‘A Voice’ I said I thought it felt like the author’s writing style had matured, and that’s definitely evident in this book. This time I was able to be totally absorbed in the story without being distracted by anything clunky. I know some reviews mentioned being frustrated by hearing so little of some characters, but I really enjoyed all the glimpses of the different families and how they live – I can’t get over how thrilling it is to read a book and EVERYBODY’s Muslim!

I’m hoping for some more about Omar and Khadijah in a future book, I just have a feeling zakiyyahh are some interesting stories there. Apr 29, Ammena rated it liked it. So, I have to say I was not zakiyyzh impressed as I was with the first 2.

Yes I cried a little in places but it didnt hit home as much as the others, maybe zakiytah I had grown used to getting to know Tamika rather than her husbands parents. The general overview footsreps this book is that it follows Sarah and her husband Ishmael as he looks into finding himself another wife in the eyes of a late 20s new muslim, masha’allah.

It talks alot about the struggles that women go through to understand this and it also So, I have to say I was not as impressed as I was with the first 2. It talks alot about the struggles that women go through to understand this and it also has a character that is the second wife of a man who is friends with Sarah. There are a few surprises and Im glad Ive read it but I would definately not add it to the list of my best books: Nov 06, Chey rated it really liked it Recommends it for: Oct 24, Hamidah rated it really liked it.

Nusaybah’s comment about not minding the “other” zakiyya business reminds me of a friend’s similar sentiments Aakiyyah 12, Audrey rated it it was amazing. Qurat-ul-ain rated it it was amazing Aug 07, Abeer Mirza rated it it was amazing Mar 05, Haleemah rated it liked it Jul 22, Raheemah rated it really liked it Oct 24, April rated it it was amazing Sep 02,


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Read Download Online Free Now eBook Estaras Ahi Will You Be There By Guillaume Musso [PDF EBOOK EPUB. KINDLE]. 1/8. Get Instant Access. Guillaume Musso. Published by Maeva Ediciones S A (). ISBN ISBN New Softcover Quantity Available: 1. Seller. Seras-tu là? has ratings and reviews. Jodie said: A not very interesting or particularly well written story. There were just a few touching sce.

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Goodreads helps you keep track of books you want to read. Want to Read saving…. Want to Read Currently Reading Read. Refresh and try again. Open Preview See a Problem? Thanks for telling us about the problem.

Return mksso Book Page. Preview — Will You Be There? Will You Be There? There is a question that everybody, at least once in a lifetime, must have come up with: If you had to do it again, what remorse, what regret would you choose to obliterate? eataras

Will You Be There?

Elliott has been professionally very successful. He is a sixty-year-old famous surgeon who lives in San Francisco and whose private lif There is a question that everybody, at least once in a lifetime, must have come up with: He is a sixty-year-old famous surgeon who lives in San Francisco and whose private life is illuminated by his daughter Angie. One day, by a strange combination of circumstances, he is brought back to his own past and meets the young man he had been thirty years earlier.

In that time, Elliott was a passionate, enthusiastic and ambitious young doctor. In San Francisco, where he met with Ilena, the Seventies were going full swing. Hardcoverpages. San Francisco, California United States.

To see what your friends thought of this book, please sign up. To ask other readers questions about Will You Be There? See 1 question about Will You Be There? Lists with This Book. This is a great romantic suspense novel, with a hint of fantasy – consistent with Guillaume Musso’s formula that works like a well-oiled machine.

After reading several of Musso’s books, one might feel a certain pattern, involving an impossible love story that eventually becomes a delightful reality, with the script of a romantic comedy, including the witty punchlines at the end of each chapter or “scene”. But hey, it works! The writing is wonderful, almost addictive, the kind that makes you think This is a great romantic suspense novel, with a hint of fantasy – consistent with Guillaume Musso’s formula that works like a well-oiled machine.

The writing is wonderful, almost addictive, the kind that makes you think “Okay, just one more chapter! And so it happened that I found myself reading this book cover to cover in just one night! Sixty-year-old Elliott has never gotten over the death of the love of his life, Ilena, who died in a tragic accident thirty years ago.

He gets a chance to go back in time and see her one last time. He receives ten pills, each one leading him to a brief encounter with his life thirty years ago – and each encounter has its own implications. Should Elliott use the knowledge he has over future events to save Ilena, no matter the consequences? The plot may offer some “easy fixes” to the complexity of time travel, but still this book is so compelling that you’d just have to forgive Musso for his inaccuracy.

As for the ending, I will invoke my right to remain silent and let you decide for yourselves! Ova knjiga je jedna velika avantura koja nam o svemu tome govori. Dec 11, Leo C.

Todos guilluame lo hemos preguntado por lo menos una vez: Aunque el final me ha dejado un poco con la boca abierta esperand Todos nos lo hemos preguntado por lo menos una vez: De esas, hay pocas View all 17 comments. On se demande bien en lisant: I loved this book! I love the time travel stories, the idea of changing the past in order to change the present is fascinating, also it’s a very emotonal story about love and friendship. En cuanto a la historia le tenia muchas ganas y no me ha decepcionado ni un poco.

El final pues hubiera preferido que hubiera unas cuantas paginas que explicaran lo que paso despues pero no me quejo fue hermoso. Por este tipo de libros es que amo leer Romanul ” Vei fi acolo? Romanul ” Vei Romanul ” Vei fi acolo? Just utterly marvelous to read this book. What would we tell ourselves if we could meet ourselves in the future. These are some of the questions which come to mind when reading this story which is so beautifully penned, thought provoking and exciting ahj well.

The book is gripping almost a thriller experience in such a lovely way. I loved the character of the book, he is so devoted to his work and himself but i Readers!

I loved the character of the book, he is so devoted to his work and himself but is sensitive of situations around him.

I love the constant back and forth of time travel, leaving us seeking more. The love story between the characters is enigmatic, enchanting, loving and very realistic as well Much much love, Sc: It will haunt you and, trust me, you will be thinking about it long after you read it.

Elliot and Ilena- mussp main characters- are delicately written and their story will take your breath away. Kudos to Musso for creating such a powerful and at the same time heartbreaking plot. One of my favorite books ever. The plot twist at the end will not let you ever ai this book – at least that’s my personal experience. E’ il terzo libro di Musso che leggo dopo “Central Park” e “la ragazza e la notte”.

Non bisogna estarad nel tranello delle copertine che rimandano al “romance” o ad artwork anni 70 in stile James Bond. Iniziano i viaggi nel tempo del vecchio Elliot che sbalordito si trova per la prima volta ad incontrare il suo omonimo giovane; questo avviene per 20 minuti in un momento preciso del sonno dopo di che ritorna alla wstaras dimensione temporale.

E una domanda per noi lettori, ogni nostra scelta porta inevitabilmente delle conseguenze nel breve e nel lungo periodo.

Se potessimo tornare indietro nel tempo rifaremo tutto daccapo o cambieremo qualcosa col famoso guillayme di poi? Matt, Ilena, la figlia Angie, Vagabondo il labrador compagno di una vita. E all’interno agi un contenitore di malinconie e occasioni perdute una girandola di sentimenti, di amicizia, di amore, di solitudini, di incontri, di profumi, di mare, di sole, di cieli azzurri. Prachtig boek en mooi hoe steeds tussen 30 jaar terug en de hoofdpersoon op jarige leeftijd wordt gewisseld.

Ook alle subtiele verwijzingen naar bijvoorbeeld opkomst van Apple hierin maakte het een bijzonder verhaal en knap gedaan dit er allemaal in te verwerken. Eigentlich hat Eliott mit seinem Leben abgeschlossen und er wartet nur noch auf den Tod.

Seras-tu là?

Anfangs skeptisch, wirft er sich dann doch eine ein. Was hat er schon zu verlieren. Kann er dieses Mal den tragischen Tod seiner Geliebten verhindern? Klar hab ich den Namen ab und an mal gelesen, aber bisher war mir nicht klar, welch ein grandioser Autor sich hinter diesem Namen verstecken muss.

Estaras Ahi/ Will you be There?: Guillaume Musso, Teresa Clavel: : Books

So ging es mir. Dabei war ich nach 50 Seiten noch wirklich skeptisch. Goldene Pillen, die einen Menschen in die Vergangenheit transportieren? Ja ne, is klar… Hinzu kam, dass einem als Leser der Einstieg etwas schwer gemacht wird.

Die Handlung springt immer wieder zwischen zwei Zeitebenen hin und her.

Daher war ich mir fast sicher, dass ich den Verlauf des Buches vorausahnen konnte. Doch nach und nach stellt sich heraus, dass Musso sich da doch hat noch etwas einfallen lassen. Denn jede Zeitreise hat einen Nebeneffekt, den jeder von uns kennt. Ein zauberhaftes Buch mit vielschichtigen Charakteren Totel verliebt war ich aber in Matt, Eliotts besten Kumpel und das in beiden Zeitebenen. Dieser Mann ist der Inbegriff der Machos.

Er geht mit einer Leichtigkeit durchs Leben, die fast bewundernswert ist. Musso kann einfach schreiben. Er schreibt eine Liebesgeschichte, ohne dass das Liebespaar zum Hauptgegenstand wird. Das war ein Fehler! Nicht nur, dass er schreiben kann, sondern er scheint auch recht gute Ideen zu haben. Mit dieser Geschichte hat er mich total unvorbereitet von den Sohlen gehauen. Ich hab mit Eliott gelacht und geweint und wollte mich kaum von ihm und seinem Leben trennen.

Le doy cinco estrellas por que llevo enganchada al libro desde las 21,00 de la noche, sin parar, devorando hoja tras hoja, ansiosa de saber que sucede con Matt, Elliot, Angie, Ilena Es una novela sencilla que habla de amor. Amor de pareja, de amigos, de padre-hija Es triste pero a la vez da un mensaje lleno de vida y esperanza. Fantastic characters and a deeply moving story.


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antimicrobial dose doxycycline and Non-Surgical. Periodontal Therapy. The main outcomes sought were host modulation therapeutics in periodontics. Exclusion. ABSTRACT. The etiology of chronic periodontitis involves complex host-parasite interactions modified by environmental and genetic factors. Contemporary. 1Department of Periodontology, Government Dental College and Research Institute Host modulation therapy has emerged in recent years as.

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Register Lost your password? As already discussed in the previous chapters, the primary etiology of periodontal diseases is bacterial infection 1. In addition modulagion bacterial etiology, the progression of periodontal diseases is adversely influenced by a number of risk factors and risk indicators like diabetes, gender, age, hereditary factors and smoking 2. Traditional treatments focused on reducing the bacterial load through scaling and root planning, but they were not effective in every patient.

Host modulation therapy HMT is a treatment concept that aims to reduce tissue destruction periodojtics stabilize or even regenerate the periodontium by modifying or down-regulating destructive aspects of the host response and up-regulating protective or regenerative responses. The purpose of HMT is to restore the balance, on one hand, between pro-inflammatory and anti-inflammatory mediators and on the other hand between destructive enzymes and their inhibitors. They can be systemically administered or locally delivered and used as adjuncts to scaling and root planning 4.

The underlying biological mechanisms of this response are characterized by the expression of hosy cell and intercellular adhesion molecules and by the production of host-derived inflammatory mediators, including, cytokines and lipids by neutrophils, monocytes, lymphocytes and fibroblasts.

The balance between inflammatory mediators and their counter-regulatory molecules is crucial for determining the outcome of the immuno-inflammatory pathology of periodontal diseases.

In the case of stable gingivitis lesion, the pro- and anti-inflammatory response is supposed to be in balance, whereas the response is skewed towards the predominance of pro-inflammatory reactivity in progressive periodontitis lesion. As present data suggest that modilation diseases have got a multi-factorial etiology, the risk factors are equally important in the final outcome of the disease progression. Before we go through the therapeutic agents used in host modulation, let us first try to understand the steps where these agents modulate the host response.

Many studies have indicated that the biological activity of a variety of cytokines may be directly relevant to periodontal destruction 7, 8. IL-1, IL-6, and tumor necrosis factor TNF have all been found to be significantly elevated in diseased periodontal sites as compared to healthy or inactive sites Cytokines have a synergistic effect.

Acting together pro-inflammatory cytokines amplify the inflammatory condition. As already explained in the previous sections, the balance between the pro and anti-inflammatory cytokines is crucial in the periodontal health and disease.

Imbalances between these mediators in the periodontal tissues are a major cause of periodontal destruction Pentoxifylline PTX is a ……………………. Buy Now For International Users: The activity of MMPs can be modulated by various ways which include, modulation of the production of MMPs, blocking activation of the proenzyme, blocking the activity of the enzyme, and activating MMP inhibitors The MMPs are a family of zinc- and calcium-dependent endopeptidases secreted or released by a variety of infiltrating cells i.

MMPs include collagenases, gelatinases, and metallo-elastases. MMPs have been strongly associated with periodontitisand excellent reviews have been published discussing the role of MMPs in periodontal diseases 22, While experimenting on germ-free diabetic rats Golub et al. Ten different chemically modified tetracyclines CMTs have been developed, 9 of which inhibit MMPs and do not possess antimicrobial modulatoin In further studies using these different tetracyclines, Golub et al 34 reported that…………….

It is indicated as an adjunct to scaling and root planning SRP taken twice daily for a period of months in the treatment of chronic periodontitis. Various effects of sub-antimicrobial dose of Doxycycline on host response have been enumerated in Table A lot of research work has been perlodontics on SDD.

Bleeding on probing was not assessed in the meta-analysis but, in general, SDD did periodontlcs improve this parameter when compared to placebo. No significant adverse effects were reported in any of the studies. As far as bacterial resistance to the drug therapy is concerned, the resistance associated with low-dose doxycycline therapy has not been seen The fact that NSAIDs can suppress alveolar bone resorption suggests that the synthesis of arachidonic acid metabolites may represent a critical regulatory pathway for potentially blocking periodontal disease progression activity In arachidonic acid metabolism, the cyclooxygenase pathway produces prostaglandins, prostacyclin, and thromboxane, called prostanoids.

Some prostanoids have pro-inflammatory properties and have been associated with the destructive process in the inflammatory diseases. In periodontal diseases, Prostaglandin E2 PGE2 has been extensively correlated to inflammation and bone resorption 5.

Host modulatory therapy

Multiple NSAIDs, including indomethacin 45flurbiprofen 46ibuprofen 47naproxen 48meclofenamic acid 49and piroxicam 50 have demonstrated the ability to inhibit gingivitis 50 and progression of periodontitis in both ligature-induced 45, 51 and naturally occurring periodontal disease in animal models Bacteria and their products like lipopolysaccharides LPS initiate an inflammatory response when they are countered by the protective host response.

These include lipoxins, aspirin-triggered epi-lipoxins ATLsresolvins, docosatrienes, and neuroprotectins. These mediators can be inhibited by NSAIDs, which include various drugs such as aspirin, ibuprofen, ketorolac, flurbiprofen, naproxen, etc. Periodontitis is characterized by the alveolar bone loss.

One of the therapeutic modality of host modulation is to stop the alveolar bone resorption. They have a primary indication of inhibiting bone resorption and thereby maintaining bone density They are used widely in conditions such as neoplastic hypercalcemia, multiple myeloma, and bone metastases secondary to breast and prostate cancer, suggesting a direct antitumor effect of bisphosphonates. Chemically bisphosphonates are pyrophosphate analogs characterized by two C-P bonds Figure These drugs can be subdivided into the nitrogen-containing bisphosphonates and non-nitrogen-containing bisphosphonates Small changes in the structure of the bisphosphonates can lead modulatiom extensive alterations in their physicochemical, biological, therapeutic, and toxicological characteristics.

Bisphosphonates are classified into three generations according to the R1 and R2 groups present in their chemical structure Table R2 group contains nitrogen but within a heterocyclic group.

Bisphosphonates work by inhibiting the precipitation of calcium phosphate even at very low concentration They also slow down the dissolution of these crystals Modulatipn these effects appear to be related to the marked affinity of these compounds for the periodohtics calcium phosphate to which they bind These compounds inhibit osteoclastic activity by blocking acidification by local release and represent a class of chemical structures related to pyrophosphates The effects of bisphosphonates at tissue level, cellular level, and molecular level are summarized in Table A serious adverse effect of bisphosphonates that has substantial dental implications is periofontics of the jaws Table.

Good dental hygiene reduces the risk modulqtion osteonecrosis. A lot of research work has been hhost on bisphosphonates and periodontitis. Sodium alendronate treatment in experimental periodontitis in Wistar rats was studied and the results showed that sodium alendronate preserves alveolar bone resorption and has anti-inflammatory and antibacterial activities in experimental periodontitis MMP Inhibition and down-regulation by bisphosphonates has also been demonstrated in one study, which observed the inhibition of MMP-1, -2, -3, -7, -8, -9, and by clodronate, alendronate, pamidronate, zoledronate, and inordinate Recent studies have demonstrated that osseointegration of titanium implants can be significantly reinforced with a nanostructure treated with anodic oxidation and heat treatment.

Results showed that surface loading with bisphosphonates significantly improved the degree of osseointegration of titanium implants with a nanostructure As it is well modulatiln that CMTs inhibit the MMPs so are indirectly involved in inhibition of bone resorption in periodontal diseases. Mdulation endocrine system plays an important role in the homeostasis of the periodontium Osteoporosis, which is defined as a systemic condition characterized by pwriodontics decrease in the bone mineral density by at least 2.

It is a major cause of morbidity and mortality in post menopause women. The American Academy of Periodontology considers osteoporosis to be a risk factor for periodontal disease Hormone replacement therapy HRT is used to relieve these symptoms and improve the psriodontics of life of peri- or post-menopausal women 80, Many studies have suggested that using HRT in post-menopausal women can decrease the periodontal destruction 79, 82 and increase tooth retention Root surface conditioning, growth factors, and cytokines can be used to promote periodontal regeneration.

Growth factors and hormones, including platelet-rich plasma PRPbone morphogenic proteins BMPsplatelet-derived growth factor PDGFparathyroid hormone PTHand enamel matrix derivatives EMD have shown promise in enhancing regeneration, although their long-term predictability remains questionable, and their anticipated benefits are moderate 86, Since then a lot of research has been done on periodontal regeneration.

Regeneration has been broadly divided into two categories; graft associated and non-graft associated. Nitric oxide NO is a free radical involved in host defense that can be toxic when present in high concentrations and it bost been implicated in a variety of inflammatory conditions. NO is produced by a wide variety of cells and appears to be an important regulator of various physiologic processes in both animals and humans NO imbalances have been noted in a variety of chronic infectious and inflammatory conditions, including, periodontal disease Nitric oxide synthase NOS exists in the body in three distinct isoforms: The importance of NO in bone formation and remodeling has been highlighted from the observations of defective bone formation, volume, turnover, and osteoblast function in eNOS and iNOS deficient mice The role of NO in periodontal ih has been well investigated.

LPS and other antigenic substances from putative periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescensand Fusobacterium nucleatum have been shown to induce the iNOS expression and NO production in murine ln It has been demonstrated that iNOS expression and activity is induced in gingival fibroblasts and neutrophils, following the stimulation by periodontal pathogens, cytokines, and other inflammatory mediators Along with this, neutrophils isolated from periodpntics aggressive periodontitis patients were shown to display increased iNOS activity and subsequent chemotactic defects …………….

As we know that bacterial biofilm present in the gingival sulcus around the tooth is a source of various bacterial components and products, which initiate the host response. First of all the innate immune system modullation the infection, but when not controlled, the acquired immune system is activated.

Within days a robust inflammatory response is generated, which initiates the connective tissue destruction. Now this activation is done by various cellular signaling mechanisms, which leads to the synthesis of various cytokines and other inflammatory chemical hozt. When a signal is generated, modulatino travels through the cytoplasm moduulation reaches the nucleus, and ultimately the pattern of gene expression is altered by transcriptional and post-transcriptional periodontixs.

Signal transduction depends on receptor-ligand interactions, which usually involves some modification on the cytoplasmic proteins associated with these receptors.

Host modulation therapeutic agents in periodontics –

The most common modification associated with signal transduction is phosphorylation of specific amino acid residues by kinases, which induces a conformational change in the tri-dimensional structure of the protein. In the process of intracellular signaling, energy is transferred at every step which modulates the biological activity of the proteins involved.

The MAP kinases are a large family of protein kinases which are involved in cellular signaling pathways in various biological processes. These are involved in signal transduction of extracellular hormones, growth factors, and cytokines MAPKs are further divided into three classes: During inflammation, MAPK pathways particularly, p38 are involved in the increased expression of various cytokine genes by modulation of both transcriptional and post-transcriptional mechanisms.

Studies have demonstrated that inhibition of JNK and ERK pathways may effectively inhibit the production of pro-inflammatory mediators Furthermore, the MAPK inhibitors have been shown to be capable of reducing inflammation in inflammatory conditions like rheumatoid arthritis and periodontal disease Studies have shown that the inhibition of these signaling pathways can lead to the reduction in the synthesis of pro-inflammatory periodnotics. These findings have been demonstrated in patients with inflammatory diseases such as rheumatoid arthritis and periodontal disease However, more human trials are modluation to prove their efficacy as host modulation agents in periodontal diseases.


DR – read user manual online or download in PDF format. Pages in total: Download LG DR service manual & repair info for electronics experts. [READ] Lg Dr Manual [EPUB] [PDF]. Book file PDF easily for everyone and every device. You can download and read online Lg Dr Manual file PDF.

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Should the unit require maintenance, contact European representative: Use of controls, adjustments or the performance of procedures other than those Veluwezoom 15, AE Almere, The specified herein may result in hazardous radiation exposure. Copyrights Recording equipment should be used only for lawful copying and you are advised to check carefully what is lawful copying in the area in which you are making a copy. Copying of copyright material such as films or music is unlaw- ful unless permitted by a legal exception or consented to by the rights owner.

The table below shows manhal specific compatibility differences depending on the disc types. Accesses or removes the HOME menu.

Accesses menu on a DVD disc. Stops playback or recording. Press repeatedly to set the recording time.

LG DR389 User Manual

Change the settings of a channel manually. Auto setup [Station Rename]: Change a name of the selected channel. When the first time to turn on the unit, the initial setup [Delete]: Delete the selected channel from programmed channel list. Adjust the general settings [Decoder]: Adjust the language settings Sampling Freq.

Frequency — Selects the sampling frequency of the audio signal. The digital audio signals are output in their original format upto 48 kHz. See recording time of each mode on page Before finalizing, check the characterisics between the disc type in the table Displaying disc information below. Timer Recording Maanual Editing a title Even though the msnual is set, the unit will not record when: Before editing Chapter search Video This unit offers various edit options for various disc types.

Before you edit, You can select the start of a title by searching a chapter. Select a title that you check the disc type, and select the option available for your disc. Time search Deleting a part Video You can select the start of a title by searching time. Select a title that you want You can delete a part which you do not want in the title.

Naming a title Protect a title When a title is recorded by this unit, the title name will be named by a number. Use this function to protect a title against accidental recording, editing or delet- You can change a title name by using this function. Language Codes Use this list to input your desired language for the following initial settings: Troubleshooting Cancel the Rating function or change the rating level.

Cannot play a disc recorded using this unit on other player. General Finalize the disc. Check the disc compatibility of the player. The power does not turned on.

LG DR Product Support :Manuals, Warranty & More | LG SouthAfrica

Place the disc on the disc tray correctly inside the guide. Plug the power cord into the wall outlet securely. TV is not Stereo-compatible. Broadcast program is not ,g stereo format. Resetting the manuao If you observe any of the following symptoms. The unit is plugged in, but the power will not turn on or off.

Page of 32 Go. Table of Contents Add to my manuals Add. Lg dkexb; dkexb; dkexb dvd video player 50 pages. Page 2 Should the unit require maintenance, contact European representative: Page 3 Copyrights Recording equipment should be used only for lawful copying and you are advised to check carefully what is lawful copying in the area in which you are making a copy. Table Of Contents Contents Before you start Auto Setup [Program Edit]: Page 16 Adjust the language settings Sampling Freq.

Displaying Disc Information Before finalizing, check the characterisics between the disc type in the table Displaying disc information below. Page 26 Before editing Chapter search Video This unit offers various edit options for various disc types. Page 27 Time search Deleting a part Dg389 You can select the start of a title by searching time. Page 28 Naming a title Protect a title When a title is recorded by this unit, the title name will be named by a number. Language Codes Language Codes Use this list to input your desired language for the following initial settings: Troubleshooting Troubleshooting Cancel the Rating function or change the rating level.

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Congratulations for choosing a quality product from FRÖLING. The FRÖLING Turbomatic waste wood boiler features a state-of-the-art design that conforms to all. View and Download Froling Turbomatic 28 – 55 kW operating instructions manual online. waste wood boiler. Turbomatic 28 – 55 kW Boiler pdf manual download. Manuals and User Guides for Froling Turbomatic 70 – kW. We have 1 Froling Turbomatic 70 – kW manual available for free PDF download: Operating.

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Unlike fossil fuel, wood is a renewable form of energy.

Biomass boilers are very efficient. Sophisticated control systems and burn efficiency means tubomatic heat and fuel are not wasted. There is very little ash, and the small amount that is produced can go straight onto your garden as fertilizer. Wood is a very versatile fuel and can be burned in many different forms to provide space and water heating.

Froling Turbomatic 28 – 55 kW Operating Instructions Manual

The most common forms are logs, chips and pellets. Historically wood fuelled heating had it draw backs as it lacked controllability. This is no longer the case with wood fuelled boilers and stoves using thermostats to program temperature settings. Logs are the most common form of wood fuel available in the UK. Wood chips are simply wood that has been utrbomatic to a consistent vroling. Wood chips can be made from either recycled wood or specially grown crops e.

Wood chips require less processing than wood pellets but have a lower energy density less energy per tonne. They therefore require much more storage space and a larger fuel handling systems to enable then to run unaided for the same tugbomatic span as pellets.

As such wood chips are not generally suitable for outputs less than 50KW most domestic situations.

Overview of pellet boiler

Wood pellets in the form of sawdust, recycled pallets or specially grown crops such as willow coppice are dried and processed into easily combustible pellet form. As with logs, pellets can be used to fuel stoves and pellet burning boilers.

Pellet boilers require less attention compared to both log and chip systems and are the most convenient wood fuel to use for a domestic setting. Integral fuel hoppers store enough pellets for 1 — 3 days operation and the ash pan only needs to be cleaned out between a month and once a year depending on the boiler.

When connected to a large store the boiler can be supplied with pellets for up to one year, enabling cheaper bulk deliveries. Wood pellets require a lot less storage space than logs or wood chip. Green Warmth supply and install a range of quality biomass boilers for logs, pellet and chip installations ranging from 10 kw for the smallest domestic pellet boilers through to kw for ftoling largest chip boiler for commercial installations.

The basic rule of thumb is the cheaper the model the higher the level of maintenance required. A more expensive boiler would only need the ash pan empting one or twice in a heating season depending on the size of the boiler. A lower priced boiler would need to be cleaned and turbomatif its ash pan removed once a week, amounting to about 30 minute work per week. Please see table below for the biomass solutions we can provide: Testimonials Just a quick note to say the biggest Thank You possible for all your hard.

Logs Logs are the most common form of wood fuel available in the UK.

Chip Wood chips are vroling wood that has been chipped to a consistent size. As such wood chips are not generally suitable for outputs less than 50KW most domestic situations Pellets Wood pellets in the form of sawdust, recycled pallets or specially grown crops such as willow coppice are dried and processed into easily combustible pellet form. Heat Pumps The earth, water and air have the ability to absorb and store heat from the sun Heat Pumps read more Biomass Boilers Unlike fossil fuel, wood is turbomafic renewable form of energy.

Pellet heating system and pellet boiler manufacturer from Austria – Fröling

Solar Solar Heating is a rapidly growing market in the UK. As solar thermal technology does Solar read more Under Floor Heating Under floor heating works by pumping controlled flows of warm water from a heat Under Floor Heating read more Heat Recovery read more Other Services We can provide solutions for other renewable energy products, depending on the requirement. Other Services read more


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